The most common side effects are mild and include localized skin dryness, itching, and temporary flaking. These are primarily caused by the active ingredients accelerating skin cell turnover. To prevent this, apply Minoxidil to a clean, completely dry surface, and incorporate a hydrating product like Peppermint Moisture Serum after the 4-hour absorption window. If irritation persists, try applying a slightly smaller dose or temporarily dropping to once-a-day application until your skin adjusts.